Isaakios 2 was a patricius and was exarchus Italiae from 625/626 to 643/644. When he died (in 643 or 644) he was buried in Ravenna, where his sarcophagus long survived in San Vitale; on the sarcophagus was an inscription giving details of his life; he was an Armenian, of noble family, married to a lady called Sosanna, and had held military commands in the East and the West; his western command (as exarchos) lasted for eighteen years: CIG 9869. Another inscription from Comaclum near Ravenna records the burial there of his eleven-year-old nephew, son of his brother: CIG 9870. For details of his career before 641, see PLRE III, pp. 719-721, s.v. Isaacius 8. In 643 or 644 he sent Donos 1 to crush the rebellion of Maurikios 7 at Rome; he then had Maurikios 7 beheaded and his head put on display in the circus at Ravenna; shortly afterwards he himself suddenly fell ill ("divino ictu", perhaps a stroke) and died, before he could decide what to do with the other rebels: Lib. Pont. 75. 1-2 (called "Isacius patricius"). He was succeeded as exarchos by Theodoros 163.

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