Michael 21 was bishop of Pamphilon (location uncertain; possibly in Thrace or Thessalia); in 787 he attended the Second Council of Nikaia (the Seventh Ecumenical Council) and was probably present at the last seven sessions, from 26 September to 23 November 787 (he is not attested at the first session): Mansi XII 1110-XIII 486. In the list of those present at the seventh session he is styled Μιχαὴλ ἐπισκόπου Παμφίλου: Mansi XIII 372. Elsewhere he is styled Μιχαὴλ ὁ ὁσιώτατος ἐπίσκοπος τοῦ Παμφύλου or similar: Mansi XII 1110 (τοῦ Παμφύλου), XIII 149 (τοῦ Παμφίλου), XIII 397 (τοῦ Παμφύλου). At the second session he supported the traditional veneration of icons as described in statements from pope Hadrian I (Hadrianos 1) and condemned iconoclasts: Mansi XII 1110. At the fourth session he subscribed the statements read out from the Fathers in support of the veneration of icons: Mansi XIII 149. At the seventh session he subscribed the statement of the faith adopted by the Council: Mansi XIII 397.

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